uniQure N.V. (NASDAQ:QURE) is a biotechnology company that focuses on developing gene therapies to treat genetic disorders. The company is known for its innovative approach in the field of gene therapy, aiming to provide long-term benefits to patients with rare diseases. uniQure's competitors include other biotech firms like REGENXBIO Inc., Voyager Therapeutics, Inc., Ultragenyx Pharmaceutical Inc., and Blueprint Medicines Corporation, all of which are involved in similar therapeutic areas.

In evaluating uniQure's financial performance, the Return on Invested Capital (ROIC) is a critical metric. uniQure's ROIC stands at -23.80%, which is significantly lower than its Weighted Average Cost of Capital (WACC) of 10.24%. This negative ROIC indicates that the company is not generating enough returns to cover its cost of capital, resulting in a ROIC to WACC ratio of -2.32.

Comparatively, REGENXBIO Inc. has a ROIC of -37.81% and a WACC of 9.85%, leading to a ROIC to WACC ratio of -3.84. This suggests that REGENXBIO is less efficient in utilizing its capital compared to uniQure. Similarly, Voyager Therapeutics, Inc. reports a ROIC of -42.29% against a WACC of 8.58%, resulting in a ROIC to WACC ratio of -4.93, indicating even lower capital efficiency.

Ultragenyx Pharmaceutical Inc. presents a more challenging scenario with a ROIC of -63.41% and a WACC of 6.61%, leading to a ROIC to WACC ratio of -9.59. This is the least favorable among the peers, showing significant inefficiency in capital utilization. On the other hand, Blueprint Medicines Corporation, with a ROIC of -17.59% and a WACC of 8.26%, achieves a ROIC to WACC ratio of -2.13, the best among the group, though still negative.

Overall, while all these companies are currently operating at a loss relative to their cost of capital, uniQure's performance is relatively better than most of its peers, except for Blueprint Medicines Corporation. This analysis highlights the challenges faced by biotech companies in achieving profitability and efficient capital utilization in the competitive landscape of gene therapy.