The U.S. stock market saw some dramatic moves past week with five stocks posting the largest weekly gains and drops (Mon-Fri Oct 6-Oct 10, 2025). For each, we highlight the drivers of the move and year-to-date (YTD) performance.

To track momentum in real time, you can use FMP's Top Traded Stocks API to see the most actively traded names. With your FMP API key, the Investor Dashboard provides a comprehensive view with deeper context - insider trades, stock price targets, revenue segmentation, and EPS trends.

Top 5 Gainers/Losers

Applied Digital (APLD) — Top Gainer (~+20% this week)

Blew past expectations and disclosed a major CoreWeave lease expansion tied to AI data-center demand, sending shares sharply higher. YTD: roughly +335% into early October.

Akero Therapeutics (AKRO) — Gainer (~+17% this week)

Popped after Novo Nordisk agreed to acquire Akero for up to $5.2B ($54 cash + $6 CVR), validating EFX's late-stage MASH program. YTD: ~+92%; trend remained strong into October. Watch: deal timing and regulatory review.

PepsiCo (PEP) — Gainer (~+7% this week)

Beat Q3 estimates and announced a CFO transition; shares firmed on international strength and “healthier drinks” momentum. YTD: around -0.09% into Oct 10.

Levi Strauss (LEVI) — Loser (~-12% this week)

Stock slid despite an upbeat Q3 and raised FY outlook, as management guided to a tariff-hit margin in Q4. YTD: still up ~22% into this week.

Qualcomm (QCOM) — Loser (~-9% this week)

Chip names lagged as U.S.-China tensions flared; QCOM also faced pressure on reports of a Chinese antitrust probe, weighing on semis broadly. YTD: roughly -0.03% into Oct 10.

Track Market Liquidity in Real Time with FMP's Top Traded Stocks API

The Top Traded Stocks API shows which tickers are commanding the most attention right now—a handy complement to weekly performance:

• Most Active Lists: Instantly see the highest-volume stocks across major U.S. exchanges (or filter by NASDAQ/NYSE).
• Real-Time Volume + Price Metrics: Monitor volume, price change, and % change to gauge momentum and liquidity.
• Company Snapshot: Pull names, symbols, and trading volume for quick context.

Example use case: A day trader scans NASDAQ via the Top Traded Stocks API and spots iSun (ISUN) printing unusually high volume. With real-time volume and price-change data in hand, they can decide whether the momentum fits their setup before entering a trade.