Karyopharm Therapeutics Inc. (KPTI)


-0.04 (-2.55%)
Symbol KPTI
Price $1.335
Beta -0.012
Volume Avg. 2.32M
Market Cap 152.664M
Shares () -
52 Week Range 1.11-6.01
1y Target Est -
DCF Unlevered KPTI DCF ->
DCF Levered KPTI LDCF ->
ROE 207.18% Strong Buy
ROA -47.54% Strong Sell
Operating Margin -
Debt / Equity -249.95% Sell
P/E -0.87
P/B -2.14 Strong Sell


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Mr. Richard A. Paulson M.B.A.
NASDAQ Global Select

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases. The company discovers, develops, and commercializes novel and Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1. Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma, and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. The company has license agreement with Menarini Group to develop and commercialize NEXPOVIO for human oncology indications in Europe, including the United Kingdom; Latin America; and other countries. Its oral SINE compounds also designed to force nuclear accumulation in the levels of multiple tumor suppressor and growth regulatory proteins. The company was incorporated in 2008 and is headquartered in Newton, Massachusetts.